Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys S Allan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
    1. Chromosomes and Gene Expression

    Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

    Lingbo Li, Samuel Hunter ... Gongyi Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Inadequate
    1. Chromosomes and Gene Expression

    Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    Roberta Carloni, Tadhg Devlin ... Robin C Allshire
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
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