CAMKII and Calcineurin regulate the lifespan of C. elegans through the FOXO transcription factor DAF-16
Li Tao, Qi Xie, Yue-He Ding, Shang-Tong Li, Shengyi Peng, Yan-Ping Zhang, Dan Tan, Zengqiang Yuan, Meng-Qiu Dong
Correspondence: Meng-Qiu Dong / National Institute of Biological Sciences, Beijing
Longevity in C. elegans is influenced not only by insulin/IGF-1 signalling, but also by CAMKII and calcineurin, acting on the same target, the transcription factor DAF-16.
Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model
Jingheng Cheng, Daoyun Ji
Correspondence: Daoyun Ji / Baylor College of Medicine
In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.
Arabidopsis plants perform arithmetic division to prevent starvation at night
Antonio Scialdone, Sam T Mugford, Doreen Feike, Alastair Skeffington, Philippa Borrill, Alexander Graf, Alison M Smith, Martin Howard
Correspondence: Martin Howard / John Innes Centre
Plants implement arithmetic division to optimize use of carbohydrate reserves and thus maintain metabolism and growth at night.
Dismantling the Papez circuit for memory in rats
Seralynne D Vann
Correspondence: Seralynne D Vann / Cardiff University
In contrast to current models, inputs from midbrain limbic structures, but not from the hippocampus, are necessary for mammillary body contributions to memory.
Evolutionary dynamics of cancer in response to targeted combination therapy
Ivana Bozic, Johannes G Reiter, Benjamin Allen, Tibor Antal, Krishnendu Chatterjee, Preya Shah, Yo Sup Moon, Amin Yaqubie, Nicole Kelly, Dung T Le, Evan J Lipson, Paul B Chapman, Luis A Diaz, Bert Vogelstein, Martin A Nowak
Correspondence: Martin A Nowak / Harvard University
A study that models the evolution of drug resistance in tumors reveals that drugs are more effective when given in combination than sequentially, and that cure is much more likely when the drugs target different pathways.