Sequence-dependent base-pair stepping dynamics in XPD helicase unwinding
Zhi Qi, Robert A Pugh, Maria Spies, Yann R Chemla
Correspondence: Yann R Chemla / University of Illinois at Urbana-Champaign
The ability of an enzyme called XPD helicase to unwind the double helix is influenced by the DNA sequence and the availability of energy.
Decoding the neural mechanisms of human tool use
Jason P Gallivan, D Adam McLean, Kenneth F Valyear, Jody C Culham
Correspondence: Jason P Gallivan / Queen’s University
Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.
See also: Insight by Bradford Mahon
Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenburg, Peter Walter
Correspondence: Peter Walter / Howard Hughes Medical Institute, University of California, San Francisco
A compound that prevents stressors such as UV light and viral infection from downregulating protein synthesis inside cells improves memory performance in mice.
See also: Insight by Graham D Pravitt
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells
Sandra Mitrovic, Cristina Nogueira, Gerard Cantero-Recasens, Kerstin Kiefer, José M Fernández-Fernández, Jean-François Popoff, Laetita Casano, Frederic A Bard, Raul Gomez, Miguel A Valverde, Vivek Malhotra
Correspondence: Vivek Malhotra / Center for Genomic Regulation
Goblet cells secrete mucins – which are key components of mucus – in a process that is regulated by calcium ions, which enter the goblet cells via a mechanism involving a channel protein called TRPM5.
The rise and fall of the Phytophthora infestans lineage that triggered the Irish potato famine
Kentaro Yoshida, Verena J Schuenemann, Liliana M Cano, Marina Pais, Bagdevi Mishra, Rahul Sharma, Chirsta Lanz, Frank N Martin, Sophien Kamoun, Johannes Krause, Marco Thines, Detlef Weigel, Hernán A Burbano
Correspondence: Hernán A Burbano / Max Planck Institute for Developmental Biology
The late blight pandemic that included the Irish Great Famine in the nineteenth century was caused by a single Phytohpthora infestans genotype, which is distinct but closely related to the most prevalent genotype of the twentieth century.
Article available ahead of publication: http://arxiv.org/abs/1305.4206
Neuroscience: Watching the brain in action
Cell biology: Less translation, more memory
Graham D Pravitt
Building for the future