Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics
   2. Neuroscience

   Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

   Céline Petitgas, Laurent Seugnet ... Serge Birman

   Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
2. 1. Cell Biology
   2. Genetics and Genomics

   The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

   Adam D. Longhurst, Kyle Wang ... David P. Toczyski
3. 1. Genetics and Genomics

   Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging

   Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M. Karimi
4. 1. Genetics and Genomics

   From sequence to molecules: Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

   Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
5. 1. Genetics and Genomics

   Mono-methylated histones control PARP-1 in chromatin and transcription

   Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin

   Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
6. 1. Cancer Biology
   2. Genetics and Genomics

   Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

   Ting Zhang, Alisa Ambrodji ... Steven M Offer

   A genetic variant within a newly identified enhancer regulates the expression of a key pharmacogene and alters the balance between resistance and sensitivity to a widely used chemotherapeutic.
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

   Jessica Gray, Von Vergel L Torres ... Ian R Henderson
8. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

   Jason E. Stajich, Brian Lovett ... Carolyn Elya
9. 1. Genetics and Genomics

   Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

   Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

    Lauren Kuffler, Daniel A Skelly ... Gregory W Carter

    Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.