Browse our Research Articles

Page 3 of 1,459
    1. Neuroscience

    Human brain dynamics and spatiotemporal trajectories during threat processing

    Joyneel Misra, Luiz Pessoa
    Intrinsic neural attractors and extrinsic environmental inputs jointly steer the dynamic trajectories of brain activity during threat processing.
    1. Immunology and Inflammation

    Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs

    Gagandeep Kaur, Thomas Lamb ... Irfan Rahman
    Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.
    1. Cancer Biology
    2. Cell Biology

    Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

    Bei Zhang, Ting Cai ... Zhihao Wu
    The carboxyl-terminal alanine-threonine-tailed protein ATP5α helps glioblastoma mitochondria maintain a high membrane potential and keep the permeability transition pore closed, thereby promoting tumor growth and increasing resistance to apoptosis.
    1. Microbiology and Infectious Disease

    Mast cells promote pathology and susceptibility in tuberculosis

    Ananya Gupta, Vibha Taneja ... Shabaana A Khader
    Conserved mast-cell activation, marked by elevated protease expression, aligns with progressive tuberculosis across human, macaque, and murine models.
    1. Epidemiology and Global Health

    Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards

    Marie-Cécile Dupas, Maria F Vincenti-Gonzalez ... Simon Dellicour
    Post-2020, highly pathogenic avian influenza H5 circulation is characterised by spatially expanded ecological suitability, changes in key environmental predictors, and a wider range of avian species affected.
    1. Neuroscience

    Identifying regulators of associative learning using a protein-labelling approach in Caenorhabditis elegans

    Aelon Rahmani, Anna McMillen ... Yee Lian Chew
    An innovative and scalable proximity labelling method profiled proteins present in the Caenorhabditis elegans brain during learning, identifying known regulators as well as novel biological pathways.
    1. Structural Biology and Molecular Biophysics

    Allosteric effects of the coupling cation in melibiose transporter MelB

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty acyltransferase

    Wenjie W Zeng, Garrison Komaniecki ... Yuxin Mao
    A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.
    1. Neuroscience

    Executive resources shape the impact of language predictability across the adult lifespan

    Merle Marie Schuckart, Sandra Martin ... Jonas Obleser
    Analyses of self-paced reading times reveal that linguistic prediction deteriorates under limited executive resources, with this resource sensitivity becoming markedly more pronounced with advancing age.
    1. Neuroscience

    Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

    John J Marshall, Jian Xu ... Anis Contractor
    Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.