Browse the latest research

Page 2 of 1,811
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

    Tony KY Lim, Anne Ritoux ... Ewan St John Smith
    Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
    1. Microbiology and Infectious Disease

    Temporal dynamics of viral fitness and the adaptive immune response in HCV infection

    Melanie Rose Walker, Preston Leung ... Rowena A Bull
    Early immune pressure and co-occurring mutations drive changes in hepatitis C virus fitness and evolution, revealing key dynamics in the establishment of chronic infection.
    1. Neuroscience

    Mesolimbic dopamine ramps reflect environmental timescales

    Joseph R Floeder, Huijeong Jeong ... Vijay Mohan K Namboodiri
    Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.
    1. Microbiology and Infectious Disease

    Multi-omics investigation of spontaneous T2DM macaque emphasizes gut microbiota could up-regulate the absorption of excess palmitic acid in the T2DM progression

    Xu Liu, Yuchen Xie ... Jing Li
    Gut dysbiosis and specific microbiota composition promoted the absorption of excess palmitic acid in the ileum, driving its accumulation in the serum.
    1. Neuroscience

    Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

    Elise J Meijer, Marissa Mueller ... Zoltán Molnár
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Incomplete
    1. Microbiology and Infectious Disease

    The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

    Ayaka Itani, Haruto Motomura ... Norio Takeshita
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology
    2. Physics of Living Systems

    Differential interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions

    Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
Newer Older