Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology

    MCAK Recognizes the Nucleotide-Dependent Feature at Growing Microtubule Ends

    Wei Chen, Yin-Long Song ... Xin Liang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

    Janelle JY Chuah, Madalena R Daugherty, David M Smith
    A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.
    1. Biochemistry and Chemical Biology

    Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

    CJ San Felipe, Jyoti Batra ... James S Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    An aphid-resistant plant metabolite as a candidate aphicide: Insight into the bioactivity and action mode of betulin against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    Phage-displayed synthetic library and screening platform for nanobody discovery

    Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
    A phage-displayed synthetic library and screening platform offer a streamlined, cost-effective solution for nanobody discovery.
    1. Biochemistry and Chemical Biology

    Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

    Guanxing Chen, Qin Li, Jiusheng Yan
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

    Austin Tedman, John A Olson ... Jonathan P Schlebach
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

    Cong Chen, Tong-Yao Gao ... Wei-Ping Zhang
    Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage

    Joanna Krwawicz, Caroline J Sheeba ... Peter Sarkies
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Superoxide Dismutases maintain niche homeostasis in stem cell populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    • Incomplete
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
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