Highlights

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Research Article
  • Reprogramming progenitor cells

    Progenitor cells destined to become glial cells can be reprogrammed to become corticospinal-like neurons

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Research Article
  • Nanosprings probe motor proteins

    DNA nanosprings can measure stall forces in kinesin motor proteins, highlighting their potential as a new tool for force spectroscopy in biophysics.

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Reviewed Preprint Updated
  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article
  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife
  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife

Latest research

    1. Neuroscience

    Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration

    Sijia Zhao, Thomas Parr ... Masud Husain
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    Sunayana Sarkar, Harsha Sharma ... Manish Jaiswal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Individual differences drive social hierarchies in mouse societies

    Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Epidemiology and Global Health

    Assessing evidence of immune imprinting in serological patterns of influenza immune response

    Bernardo García-Carreras, Bingyi Yang ... Derek AT Cummings
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology

    PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

    Jimena Druker, Hao Jiang ... Angus I Lamond
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology

    Leveraging Disease Association Degree for High-Accuracy MicroRNA Target Prediction

    Baiming Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek Bansal, Maia Kinnebrew ... Diwakar Shukla
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

    Amit Kumar, Matthew Sanders ... Yu-ming M Huang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    A lobule-specific neuronal representation of song temporal structure in the songbird cerebellum

    Roman Ursu, Eduarda Centeno, Arthur Leblois
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete