Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Mechanics of oncogenesis

    Integrative mechanobiological approaches provide insight into the biophysics of tissue-specific tumor growth.

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Research Article

  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
    1. Genetics and Genomics

    Sibling chimerism among microglia in marmosets

    Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
    Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
    1. Neuroscience

    Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

    Kei Jokura, Piotr Słowiński ... Gáspár Jékely
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Immunology and Inflammation
    2. Neuroscience

    The G-protein coupled receptor GPR34 promotes the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimer’s disease model

    Ana Geller, Min Jee Kwon ... Prabhat S Kunwar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Lineage tracing and live-cell imaging reveal that NeuroD1 does not reprogram microglia into neurons

    Xiaoyu Li, Yuxin Li ... Yanxia Rao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Plant Biology
    2. Ecology

    Genetic canalization of nutrient resorption: evidence from a widespread grass under effective salt stress

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

    Beth A Shen, Kyle L Asfahl ... Joseph D Mougous
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Robust and replicable effects of ageing on resting state brain electrophysiology measured with MEG

    Andrew J Quinn, Jemma Pitt ... Mark W Woolrich
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths

    Aditi Vijayan, Mauro Forlino ... Monika Stengl
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
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Magazine

    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  4. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
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  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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