Highlights

  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article
  • Testing the blood-brain barrier

    pdgfrb knockout zebrafish, which lack mural cells in their neurovasculature, retain restrictive permeability of the blood-brain barrier during developmental stages.

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Research Article
  • Making of the microenvironment

    Single-cell sequencing and multi-omics approaches reveal the influence of BRCA1/2 mutations on the tumor microenvironment in lung adenocarcinoma.

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article

Latest research

    1. Developmental Biology
    2. Genetics and Genomics

    Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

    Volker Soltys, Moritz Peters ... Yingguang Frank Chan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology
    2. Neuroscience

    BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons

    Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel ... Nicolás Unsain
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Differential locus coeruleus–hippocampus interactions during offline states

    Mingyu Yang, Oxana Eschenko
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Optimising the tilt-increment for in situ cryo-electron tomography

    Maarten W Tuijtel, Tomáš Majtner ... Martin Beck
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    The Crunchometer: A Low-Cost, Open-Source Acoustic Analysis of Feeding Microstructure

    Elvi Gil-Lievana, Benjamin Arroyo ... Ranier Gutierrez
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    • Solid
    1. Epidemiology and Global Health

    Heterogeneity of use, access and retention of insecticide-treated nets: implications for subnational tailoring to maximise malaria control

    Andrew C Glover, Hannah Koenker ... Thomas S Churcher
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Neuroscience

    Cell-to-cell signalling mediated via CO2: activity dependent axonal CO2 production opens Cx32 in the Schwann cell paranode

    Jack Butler, Lowell Mott ... Nicholas Dale
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Metabolic support of trained immune responses in myeloid cells

    Aitor Jarit-Cabanillas, Gillian Dunphy ... David Sancho
    A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive TI induction and secondary metabolic adaptations providing building blocks required for enhanced immune function.
    1. Neuroscience

    Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization

    Roland Philipp, Yuki Hara ... Kazuhiko Seki
    Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.