Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Evolution in eutherian mammals

    Following the end-Cretaceous extinction, eutherian mammals in China evolved larger teeth before developing more specialised biting adaptations.

    Z Jack Tseng, Qian Li, Suyin Ting
    Research Article

  • Insights into synaptic dysfunction

    LRRK2, a protein linked to Parkinson’s disease, interacts with an actin-binding protein, drebrin, to regulate synaptic function and has a role in BDNF-dependent synaptic modulation.

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Modulating hyperexcitability

    PRRT2, a transmembrane protein, helps to limit neuronal hyperexcitability by modulating slow inactivation of voltage-gated sodium channels.

    Bin Lu, Qi-Wu Xu ... Zhi-Qi Xiong
    Reviewed Preprint Updated

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions

    Morteza Esmaeili, Erin Bjørkeli ... Alireza Salami
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

    Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson
    Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Type I and type II inhibitors differentially affect LRRK2 filament formation around microtubules, revealing an important consideration for Parkinson’s disease drug development.
    1. Cell Biology
    2. Neuroscience

    Stable excitatory-inhibitory synapse balance despite dynamic turnover

    Krassimira A Garbett, James P Allen ... Richard C Sando
    Long-term live imaging and tracking approaches reveal a coordination between excitatory and inhibitory synapse assembly, despite continual spatiotemporal dynamics.
    1. Neuroscience

    Sensory adaptation and pupil-linked arousal support flexible evidence accumulation during perceptual decision making

    Kara D McGaughey, Joshua I Gold
    Flexible evidence accumulation in dynamic environments relies on multiple mechanisms, including context-dependent modulations of sensory adaptation and pupil-linked arousal.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely Catarine Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli
    TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.
    1. Computational and Systems Biology
    2. Neuroscience

    Active dendrites enable robust spiking computations despite timing jitter

    Thomas SJ Burger, Michael E Rule, Timothy O'Leary
    The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.
    1. Immunology and Inflammation

    ITK Deficiency Attenuates Alveolar Hemorrhage by Enhancing Regulatory T Cell-Mediated Tissue Resilience

    Mohammad Saddam Hossain, Ali Mobeen ... Mobin Karimi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Magazine

    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
    1. Physics of Living Systems

    Actin Filaments: Building bundles by the numbers

    Christian Vanhille-Campos, Anđela Šarić
    1. Neuroscience

    Hippocampal Network: Stronger memories through smarter stimulation

    Justin Riddle
    1. Neuroscience

    Verbal Memory: Language acquisition in newborns

    Marcela Peña

  7. Episode 103: May 2026

  8. See more Magazine articles

Categories

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  9. Evolutionary Biology
  10. Genetics and Genomics
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  12. Medicine
  13. Microbiology and Infectious Disease
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  19. Structural Biology and Molecular Biophysics
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