Highlights

  • Replication in Drosophila studies

    An analysis of 400 articles on the immune response in Drosophila highlights a need for caution regarding the replicability of certain claims.

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Reviewed Preprint Updated

  • Tsetse fly feeding adaptations

    Investigations into the biomechanics of tsetse fly blood feeding reveal that subtle anatomical adaptations enable the penetration of a diverse range of host hides.

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Research Article

  • Anatomy of taste and texture

    Comprehensive ultrastructural reconstruction of the Drosophila larval pharyngeal sensory system reveals the organization and diversity of its sensory structures.

    Vincent Richter, Tilman Triphan ... Andreas S Thum
    Research Article

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

    Irina Bregy, Robin Benjamin Eberle ... Torsten Ochsenreiter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    The cell cycle regulates cell-penetrating peptide cytosolic uptake via differential expression of KCNH1 potassium channel

    Francisco Tomás Ribeiro, Ali Hallaj ... Christian Widmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Connectomic Analysis of Mitochondria in the Central Brain of Drosophila

    Kit D Longden, Patricia K Rivlin ... Stuart Berg
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Dawn of segmented bilaterians unveiled by soft-bodied fossils in microbial pseudomorphs from the Basal Cambrian

    Xiaoguang Yang, Deng Wang ... Jian Han
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Lipid-Driven Biophysical Selection of β-Furanoside-5’-Phosphate as the Sole Scaffold of Extant RNA

    Ze-Run Zhao, Qian-Qian Chen ... Xiao Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years

    Megan A Phillips, Robert A Petit ... Timothy D Read
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Spyglass is a framework for reproducible and shareable neuroscience research

    Kyu Hyun Lee, Eric L Denovellis ... Loren Frank
    Spyglass transforms neuroscience datasets into a foundation for discovery, enabling researchers to verify findings, test new ideas, share results, and build knowledge that extends beyond any single experiment or laboratory.
    1. Evolutionary Biology

    Class-wide sequence, structural, and docking-profile diversity of insect odorant receptors and structural specialization of Orco

    Tianmin Zhang, Xuanxiao Yang ... Huimeng Lu
    A large-scale comparative analysis reveals extensive diversity of insect odorant receptors and identifies a conserved extracellular β-sheet in Orco that helps restrict natural odorant access.
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    The temporal order of driver mutations influences colorectal cancer initiation in an immune-dependent manner, highlighting tumor–immune interactions as a context for evolutionary selection.
    1. Cell Biology
    2. Neuroscience

    A validated antibody toolbox for ALS research

    Riham Ayoubi, Emma J MacDougall ... Carl Laflamme
    A systematic characterization of antibodies targeting amyotrophic lateral sclerosis-associated proteins establishes a community resource for reliable protein detection and disease research.
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
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  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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