Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Chromosomes and Gene Expression

    Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

    Ophélie Gosselin, Michael Taschner ... Stephan Gruber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

    Naci Oz, Hetian Su ... Alaattin Kaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions

    Maria Gädeke, Tom Eric Willems ... Johannes Schultz
    Being responsible for a partner's adverse outcomes is associated with anterior insula activation, while the superior temporal sulcus tracks prediction errors for the partner's reward resulting from the participant's decisions.
    1. Neuroscience
    2. Physics of Living Systems

    A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

    Matthew W Rozak, James R Mester ... Bojana Stefanovic
    A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights into their coordination.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Adaptor protein supersaturation drives innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania

    Michaela Zwyer, Zhi Ming Xu ... Daniela Brites
    The severity of active tuberculosis in a high-burden population is not explained by host or pathogen genetic variation, suggesting a dominant role for social and environmental factors.
    1. Computational and Systems Biology
    2. Neuroscience

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
    Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
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Magazine

    1. Microbiology and Infectious Disease

    Gut Microbiome: Bacteria weigh up costs and benefits of mobile weapons

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  2. Point of View: An easy way to improve lab meetings

    Cara Glynn, Tiago Monteiro
    1. Neuroscience

    Neuropathic Pain: Closing in on the causes of chronic neuropathic pain

    Geoffroy Laumet

  4. Scientific Publishing: Rethinking how research is reviewed and published

    Timothy E Behrens, Yamini Dalal, Diane M Harper
  5. Kangaroo in Broken Hill, Australia

    Episode 102: March 2026

    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong
    1. Neuroscience

    Non-Visual Light Perception: Ancient photoreceptor shapes behavioural responses

    N Sören Häfker
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Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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