Highlights

Latest research

    1. Microbiology and Infectious Disease

    Mycobacterial Metallophosphatase MmpE acts as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Ventral Hippocampal Temporoammonic and Schaffer Collateral Pathways Differentially Control Fear- and Anxiety-Related Behaviors

    Maltesh Kambali, Muxiao Wang ... Uwe Rudolph
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Medicine
    2. Computational and Systems Biology

    Global molecular landscape of early MASLD progression in obesity

    Qing Zhao, William De Nardo ... Philipp Kaldis
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Sex–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain

    Anisa Gumerova, Georgii Pevnev ... Vitaly Ryu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Protein-induced membrane strain drives supercomplex formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

    Caroline Kikawa, Andrea N Loes ... Jesse D Bloom
    High-throughput measurement of neutralization titers using a new sequencing-based assay can help explain which seasonal influenza strains spread in the human population.
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
    Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
    1. Neuroscience

    Dynamics of mesoscale brain network during visual discrimination learning revealed by chronic, large-scale single-unit recording

    Tian-Yi Wang, Chengcong Feng ... Zhengtuo Zhao
    During the acquisition of correct rejection response, rankings of functional connection separated for cortical and subcortical regions, which is predictive of the peak timing of visual information encoding across the network.