Highlights

  • Morphogenesis in fungi

    Glycolysis orchestrates morphogenesis and virulence in fungi by regulating the de novo biosynthesis of sulfur-containing amino acids.

    Dhrumi Shah, Nikita Rewatkar ... Sriram Varahan
    Research Article
  • Metal transport breakthrough

    Researchers have identified the transport protein used by the parasite Toxoplasma gondii to import iron and zinc.

    Dana Aghabi, Cecilia Gallego Rubio ... Clare R Harding
    Research Article
  • Social tolerance in macaques

    Species of macaques with high social tolerance have larger amygdalae than species with low social tolerance. Image credit: Sarah Silvère.

    Sarah Silvere, Julien Lamy ... Sebastien Ballesta
    Research Article
  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article
  • Written out of history

    Four women whose pioneering contributions to science have been largely overlooked.

    Lisa M Thomann, Julie Batut
    Feature Article
  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife

Latest research

    1. Evolutionary Biology

    Inference of germinal center evolutionary dynamics via simulation-based deep learning

    Duncan K Ralph, Athanasios G Bakis ... Frederick A Matsen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity

    Riku Kawanabe-Kobayashi, Sawako Uchiyama ... Makoto Tsuda
    Stress activates a locus coeruleus–spinal dorsal horn noradrenergic circuit that drives mechanical pain hypersensitivity through Hes5-positive astrocytes.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

    Zachary L Reitz, Bita Pourmohsenin ... Marnix Medema
    Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Should I stay or should I go? Spatiotemporal dynamics of bacterial biofilms in confined flows

    Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Evaluation of antibiotic and peptide vaccine strategies for mirror bacterial infections

    Alexander Kleinman, Joe Torres, Brian Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Genetics and Genomics

    Systematic yeast two-hybrid screening identifies novel functions for SET1C/COMPASS

    Pierre Luciano, Kihyun Park ... Vincent Géli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Epidemiology and Global Health

    From multiplicity of infection to force of infection for sparsely sampled Plasmodium falciparum populations at high transmission

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Pupil size reveals the perceptual quality and effortless nature of synesthesia

    Christoph Strauch, Casper Leenaars, Romke Rouw
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    White Matter Stratification in Depression Predicts Multidimensional Antidepressant Responses

    Jiaolong Qin, Xinyi Wang ... Qing Lu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid