Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates

    Clémence Ligneul, Lily Qiu ... Jason P Lerch
    Diffusion-weighted magnetic resonance spectroscopy and microstructural modelling longitudinally tracks cell-specific cerebellar development to non-invasively monitor, and better understand, early brain microstructure.
    1. Ecology

    Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments

    Jing Tao, Charles A Nock ... Ji Zheng
    A novel approach has been developed to partition the net biodiversity effect into components associated with positive, negative, and competitive species interactions.
    1. Epidemiology and Global Health

    Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study

    Fernanda Morales Berstein, Jasmine Khouja ... Rebecca C Richmond
    Adiposity does not play a major role in head and neck cancer risk.
    1. Neuroscience

    Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

    Hiroki Toyoda, Doyun Kim ... Youngnam Kang
    Chronic stress impairs the autoinhibition in locus coeruleus neurons by inducing the internalization of α2A adrenaline receptors, which causes their overexcitation and consequently induces their degeneration by producing active asparagine endopeptidase.
    1. Developmental Biology
    2. Neuroscience

    Premature vision drives aberrant development of response properties in primary visual cortex

    Sophie V Griswold, Stephen D Van Hooser
    Introducing premature visual experience by opening the closed eyelids early in ferrets caused many cells in the primary visual cortex to mature improperly.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    High-content high-resolution microscopy and deep learning-assisted analysis reveals host and bacterial heterogeneity during Shigella infection

    Ana Teresa López-Jiménez, Dominik Brokatzky ... Serge Mostowy
    High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.
    1. Neuroscience

    Bayesian meta-analysis reveals the mechanistic role of slow oscillation-spindle coupling in sleep-dependent memory consolidation

    Thea Ng, Eunsol Noh, Rebecca MC Spencer
    Strong and temporally precise coupling between frontal slow oscillations and fast spindles consistently predicts memory retention across conditions, supporting its role as a fundamental mechanism in sleep-dependent memory consolidation.
    1. Cell Biology

    Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

    Claire Masson, Cyril Scandola ... Anita Eckly
    Megakaryocytes form a 3D cage of laminin and collagen IV that stabilizes them within their vascular niche, while β1/β3 integrins and MMP are key regulators that assist megakaryocyte maturation and intravasation.
    1. Neuroscience

    A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex

    Cecilia Hes, Abigail J Tomlinson ... Paul V Sabatini
    The dorsal vagal complex is a highly intricate structure composed of distinct transcriptional classes of glial and neuronal cells, exhibiting many similarities but also notable differences between mice and rats.
    1. Developmental Biology

    Distinct waves of ovarian follicles contribute to mouse oocyte production

    Qi Yin, Allan C Spradling
    The first follicle wave undergoes atresia to amplify androgen-producing theca cells, while previously unknown wave 1.5 follicles leave quiescence at 2 weeks and produce most of the earliest offspring.