Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Gene regulatory dynamics during craniofacial development in a carnivorous marsupial

    Laura E Cook, Charles Y Feigin ... Irene Gallego Romero
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Evolutionary Biology

    G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa

    Alain Garcia De Las Bayonas, Nicole King
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    DNA methylation insulates genic regions from CTCF loops near nuclear speckles

    Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis

    Simone Rencken, Georgi Tushev ... Gilles Laurent
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

    Alan Koh, Eduard Bokman ... André EX Brown
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Genetics and Genomics

    Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos

    Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler
    RNA-sensing guide RNAs provide a programmable platform for conditional, sequence-specific activation of CRISPR-Cas9 upon RNA detection in diverse biological contexts.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Refining the resolution of the yeast genotype–phenotype map using single-cell RNA-sequencing

    Arnaud N'Guessan, Wen Yuan Tong ... Alex N Nguyen Ba
    Single-cell RNA sequencing of thousands of yeast progeny reveals how gene expression differences and heritability drive phenotypic diversity.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex-classification of somatic tissues

    Chen Xie, Sven Künzel, Diethard Tautz
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
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Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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    Read public reviews for ‘A “tour-de-force” study of neuronal maturation’

    1. Genetics and Genomics

    Quantitative Genetics: Explore our collection of articles

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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Yamini Dalal
    National Cancer Institute, United States
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