Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Homologous Recombination: Snapshot of an intermediate structure

   Akira Shinohara

   Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.
2. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Structural mechanism of strand exchange by the RAD51 filament

   Luay Joudeh, Robert E Appleby ... Luca Pellegrini

   The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

   Deepak Pant, Parik Kakani ... Sanjeev Shukla

   YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.
4. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

   Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui

   Single-molecule mRNA and protein quantification, combined with stochastic modelling, uncover a post-transcriptional regulatory mechanism that controls the expression of the extremely low-abundance DNA double-strand break repair enzyme RecBCD.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   DNA methylation insulates genic regions from CTCF loops near nuclear speckles

   Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau
6. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

   Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
7. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

   Naphannop Sereesongsaeng, Carole JR Bataille ... Terry H Rabbitts
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Enalapril mitigates senescence and aging-related phenotypes by targeting antioxidative genes via phosphorylated Smad1/5/9

   Wencong Lyu, Haochen Wang ... Wei Tao
9. 1. Chromosomes and Gene Expression

   Srs2 binding to proliferating cell nuclear antigen (PCNA) and its sumoylation contribute to replication protein A (RPA) antagonism during the DNA damage response

   Jiayi Fan, Nalini Dhingra ... Xiaolan Zhao

   Srs2 binding to PCNA and subsequent Mec1-dependent sumoylation regulate RPA-mediated checkpoint signaling.
10. 1. Cancer Biology
    2. Chromosomes and Gene Expression

    Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

    Benura Azeroglu, Wei Wu ... Eros Lazzerini-Denchi

    Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.