Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Physics of Living Systems

    Exploiting fluctuations in gene expression to detect causal interactions between genes

    Euan Joly-Smith, Mir Mikdad Talpur ... Andreas Hilfinger
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology

    Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy

    See-Khai Lim, Wen-Ching Lin ... Kurt Yun Mou
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

    Irene Lamberti, Jeffrey A Chao ... Felix Naef
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    An evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuits

    Yang Shen, Arkarup Banerjee ... Saket Navlakha
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    High frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

    Michelle Jin, Simon O Ogundare ... Christine Ann Denny
    A new scalable workflow for analyzing multiple ensemble datasets incorporates SMARTTR, an R package supporting network analysis, visualization, and the import of external datasets.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

    Anshul Choudhary, Brian Q Geuther ... Vivek Kumar
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
Load more

Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Computational and Systems Biology

    International aspects of bioRxiv preprints

    Richard J Abdill, Elizabeth M Adamowicz, Ran Blekhman

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors