Cancer Biology

Latest articles

1. 1. Developmental Biology
   2. Cancer Biology

   Tumors mimic the niche to inhibit neighboring stem cell differentiation

   Yang Zhang, Yuejia Wang ... Shaowei Zhao
2. 1. Cancer Biology

   Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

   Chen Lin, Gu Yanlun ... Pang Xiaocong
3. 1. Cancer Biology

   TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer

   Laura Morano, Nadia Vezzio-Vié ... Jihane Basbous

   Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
4. 1. Cancer Biology

   Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

   Cassandra C Taber, Wenguang He ... Michael Ohh

   A unique pathogenic mutation on the primary prolyl hydroxylase of the oxygen-sensing pathway compromises the capacity to hydroxylate the hypoxia-inducible factor's N-terminal oxygen-dependent degradation domain proline while retaining activity against the otherwise catalytically predominant C-terminal proline.
5. 1. Cancer Biology

   Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

   Yao Wang, Hara Apostolopoulou ... Anil Bhushan
6. 1. Cancer Biology
   2. Computational and Systems Biology

   BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

   Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva

   BEHAV3D Tumor Profiler enables researchers without computational expertise to uncover heterogeneous cell behaviors and explore their relationships with microenvironmental features in intravital microscopy data.
7. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

   Naphannop Sereesongsaeng, Carole JR Bataille ... Terry H Rabbitts
8. 1. Cancer Biology

   KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

   Lena Lau, Kurt Henderson ... Marie Classon

   KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
9. 1. Cancer Biology

   Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

   Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
10. 1. Cancer Biology
    2. Evolutionary Biology

    Cancer–immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang

    Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.