Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Cancer Biology

    An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

    Lilong Liu, Zhenghao Liu ... Zheng Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

    Deepak Pant, Parik Kakani ... Sanjeev Shukla
    YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.
    1. Cancer Biology
    2. Cell Biology

    PRMT1-mediated metabolic reprogramming promotes leukemogenesis

    Hairui Su, Yong Sun ... Xinyang Zhao
    Glycolysis and attenuates oxidative phosphorylation through long-chain fatty acids, while mitochondrial biogenesis and anabolism remain intact, to accelerate the progression of acute megakaryocytic leukemia.
    1. Developmental Biology
    2. Cancer Biology

    Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    Denise Ragusa, Chun-Wai Suen ... Cristina Pina
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Cancer Biology

    The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

    Adam L Kenet, Sooraj Achar ... Grégoire Altan-Bonnet
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cancer Biology

    Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer

    Jianying Xu, Wenjie Shi ... Ulf Dietrich Kahlert
    A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole JR Bataille ... Terry H Rabbitts
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

    Benura Azeroglu, Wei Wu ... Eros Lazzerini-Denchi
    Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen
    The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.
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Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Cancer Biology

    Toxicity: Fishing for protective compounds

    Giuliano Ciarimboli

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Caigang Liu
    Shengjing Hospital of China Medical University, China
  4. See more editors