Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

    Cassandra C Taber, Wenguang He ... Michael Ohh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
    1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng
    A machine learning-derived multi-gene score effectively predicts radiation sensitivity in nasopharyngeal carcinoma by integrating immune characteristics and radiosensitivity-related pathways.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cancer: Reading the DNA of telomeres

    Shamayita Roy, Claus M Azzalin
    Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.
    Version of Record
    Insight
    1. Cancer Biology

    Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

    Xin Zhang, Guangyu Zhang ... Chunjie Liu
    iCAF-mediated immune escape and promoted tumor angiogenesis via VEGFA/B-VEGFR1 pathway indicate that a combination of immunotherapies and anti-angiogenic targeted therapy may be effective for H. pylori infection-associated gastric cancer.
    1. Cancer Biology
    2. Cell Biology

    RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Upregulated by HOXA10, RUNX2 isoform II transactivates PRDX2 expression and inhibits ferroptosis and apoptosis in oral squamous cell carcinoma.
    1. Computational and Systems Biology
    2. Cancer Biology

    BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Targeting cysteine metabolism could provide novel strategies for treating trastuzumab-resistant HER2-positive breast cancer.
    1. Cancer Biology

    Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

    Laleh S Arabanian, Jenni Adamsson ... Claes M Gustafsson
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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