Responding to retinal damage

Latest research

1. 1. Cell Biology

   Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A

   Annabel Cardno, Karen Roberts, Catherine Lindon
2. 1. Plant Biology

   Molecular architecture of thylakoid membranes within intact spinach chloroplasts

   Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
3. 1. Genetics and Genomics

   Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis

   Simone Rencken, Georgi Tushev ... Gilles Laurent
4. 1. Cell Biology

   Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

   Juan Long, Meng Ma ... Jing Yang
5. 1. Evolutionary Biology

   Structural evolution of nitrogenase enzymes over geologic time

   Bruno Cuevas-Zuviría, Franka Detemple ... Betül Kaçar
6. 1. Neuroscience

   Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state

   Christopher R Lee, Gillian A Matthews ... Kay M Tye

   Optogenetic manipulations and neural circuit interrogation reveal that dorsal raphe dopamine circuits can emulate different facets of a loneliness-like state, including prosociality, aversion, and vigilance.
7. 1. Chromosomes and Gene Expression

   Srs2 binding to proliferating cell nuclear antigen (PCNA) and its sumoylation contribute to replication protein A (RPA) antagonism during the DNA damage response

   Jiayi Fan, Nalini Dhingra ... Xiaolan Zhao

   Srs2 binding to PCNA and subsequent Mec1-dependent sumoylation regulate RPA-mediated checkpoint signaling.
8. 1. Biochemistry and Chemical Biology

   Phage-displayed synthetic library and screening platform for nanobody discovery

   Baolong Xia, Ah-Ram Kim ... Norbert Perrimon

   A phage-displayed synthetic library and screening platform offer a streamlined, cost-effective solution for nanobody discovery.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Trained immunity in the lung

   Elina Idiiatullina, Dane Parker

   Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
10. 1. Neuroscience

    Interleukin-4 induces CD11c⁺ microglia leading to amelioration of neuropathic pain in mice

    Keita Kohno, Ryoji Shirasaka ... Makoto Tsuda

    Increasing CD11c⁺ microglial subsets in the spinal dorsal horn by intrathecal treatment of interleukin-4 alleviate pain hypersensitivity caused by nerve injury.